Ever since discovering her lifelong best friend was sleeping with her (now ex) husband, Christine's trust in other women has been a little shaky. Sure, she has a few close friends, but she's also fiercely independent and shies away from sharing too much with them. When Ruth, one of her colleagues, hears Christine saying that she doesn't feel the need for a best friend, she wishes she could show her how enriching a good female friendship really can be. She embarks on a mission to find Christines old girlfriends in time for her forty-fourth birthday, and plots to bring them together for the surprise party of a lifetime. Of course, finding all of these women turns out to be easier said than done, but in the process, Ruth and the others helping her not only find out more about Christine's past friendships, but about their own too. Meanwhile, Christine, who has no idea of the search taking place, has some personal challenges of her own and may soon need the support of her girlfriends more than ever. This is a loving and laugh-out-loud funny portrait of one womans life, told through the stories of her friendships.